Janet

Janet 乳腺癌治疗评估与下一步方向

广州中医药大学金沙洲医院

Janet 乳腺癌治疗评估
与下一步方向

根据现有病理与影像资料整理的初步评估路径，帮助患者与家属清楚了解赴华前的准备及后续治疗方向。

HER2 强阳性 病理蜡块送检 NGS 肝脏及肺部精准放疗评估
1

目前已确认

Biopsy肺部病灶已完成活检

已有病理组织可供进一步分析。

PathologyHER2 强阳性

后续可继续评估 HER2 相关治疗选择。

Current Status肝脏及肺部均有病灶

需要结合最新影像进行整体评估。

2

前往中国前请准备

  • 肺部活检病理蜡块标本
  • 完整病理及免疫组化报告
  • 既往化疗、靶向治疗及放疗记录
  • 最新 CT / PET-CT / MRI 影像与报告

请提前向原医院申请病理蜡块，并妥善包装携带至中国，供 NGS 基因检测使用。

3

抵达中国后的评估

1肝脏增强 MRI

了解病灶数量、位置与范围

2病理蜡块送检 NGS

分析潜在基因突变及治疗靶点

3制定个体化方案

综合影像、病理与基因结果

NGS 用于寻找 HER2 以外的潜在治疗靶点，协助医生选择更精准的后续用药。

4

初步治疗方向

Systemic Treatment全身药物治疗

根据 HER2、既往用药及 NGS 结果，评估合适的靶向药物或 ADC。

Local Treatment精准局部放疗

肝脏及肺部病灶均可进一步评估局部精准放疗。

全身药物治疗 ＋ 肝脏及肺部局部放疗

以上为线上初步评估方向。最终治疗方案需结合最新影像、病理、NGS 检测结果及患者身体状况后确定。

Guangzhou University of Chinese Medicine Jinshazhou Hospital

Janet’s Breast Cancer Assessment
and Recommended Next Steps

A preliminary care pathway based on the available pathology and imaging records, prepared to help the patient and family understand the required preparations and possible treatment direction in China.

HER2 Strongly Positive Wax Block for NGS Liver & Lung Radiotherapy Assessment
1

Confirmed Findings

BiopsyLung lesion biopsy completed

Pathology tissue is available for further molecular analysis.

PathologyHER2 strongly positive

Further HER2-directed treatment options may be evaluated.

Current StatusLesions in the liver and lungs

An overall assessment should be made using the latest imaging.

2

What to Prepare Before Travelling to China

  • Pathology wax block from the lung biopsy
  • Complete pathology and immunohistochemistry reports
  • Records of previous chemotherapy, targeted therapy and radiotherapy
  • Latest CT, PET-CT or MRI images and reports

Please request the pathology wax block from the original hospital in advance and bring it safely to China for NGS testing.

3

Assessment After Arrival in China

1Contrast-enhanced liver MRI

Assess the number, location and extent of the lesions

2NGS using the wax block

Analyse potential gene mutations and treatment targets

3Personalised treatment planning

Integrate imaging, pathology and genomic findings

NGS may identify potential treatment targets beyond HER2 and help guide more precise systemic therapy.

4

Preliminary Treatment Direction

Systemic TreatmentSystemic drug therapy

Evaluate suitable HER2-targeted therapy or an ADC based on previous treatment and NGS findings.

Local TreatmentPrecision local radiotherapy

Both liver and lung lesions may be assessed for precision local radiotherapy.

Systemic Drug Therapy ＋ Local Radiotherapy to Liver and Lung Lesions

This is a preliminary recommendation based on an online assessment. The final treatment plan must be determined after reviewing the latest imaging, pathology, NGS results and the patient’s overall condition.